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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:5195
Term: furazolidone
Definition: A member of the class of oxazolidines that is 1,3-oxazolidin-2-one in which the hydrogen attached to the nitrogen is replaced by an N-{[(5-nitro-2-furyl)methylene]amino} group. It has antibacterial and antiprotozoal properties, and is used in the treatment of giardiasis and cholera.
Chemical ID: MESH:D005664
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1increases cleavageEXP 6480464CTDFurazolidone results in increased cleavage of PARP1 proteinPMID:26687534
PARP1multiple interactionsEXP 6480464CTDCDKN1A protein inhibits the reaction [Furazolidone results in increased phosphorylation of PARP1 protein]PMID:26687534
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