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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:517248
Term: bufalin
Definition: A 14beta-hydroxy steroid that is bufan-20,22-dienolide having hydroxy substituents at the 5beta- and 14beta-positions. It has been isolated from the skin of the toad Bufo bufo.
Chemical ID: MESH:C022777
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1decreases activityEXP 6480464CTDbufalin results in decreased activity of MAPK1 proteinPMID:21922632
MAPK1increases phosphorylationEXP 6480464CTDbufalin results in increased phosphorylation of MAPK1 proteinPMID:10712238
MAPK1multiple interactionsEXP 6480464CTD2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; Ro 31-8220 inhibits the reaction [bufalin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [bufalin results in increased phosphorylation of MAPK1 protein]PMID:10712238
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