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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10439
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:51687
Term: chrysene
Definition: An ortho-fused polycyclic arene found commonly in the coal tar.
Chemical ID: MESH:C031180
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1increases expressionEXP 6480464CTDchrysene results in increased expression of CYP1B1 mRNAPMID:12117779
Cyp1b1multiple interactionsEXP 6480464CTD[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CYP1B1 mRNAPMID:27858113
Cyp1b1increases expressionISOCyp1b1 (Rattus norvegicus)6480464CTDchrysene results in increased expression of CYP1B1 mRNAPMID:17961608
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDchrysene results in increased expression of CYP1B1 mRNA; chrysene results in increased expression of CYP1B1 proteinPMID:12107646 PMID:15566942 PMID:17253728 PMID:27196671 PMID:31087746
Cyp1b1multiple interactionsISOCyp1b1 (Rattus norvegicus)6480464CTD[benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [chrysene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]; [chrysene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; [chrysene co-treated with benz(a)anthracene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1B1 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene] results in increased expression of CYP1B1 mRNA; [chrysene co-treated with Benzo(a)pyrene] results in increased expression of CYP1B1 mRNA; chrysene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; chrysene promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]PMID:15315710 PMID:37189300
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