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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621812
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cxcl3
Name: C-X-C motif chemokine ligand 3
Acc ID: CHEBI:5134
Term: fluticasone
Definition: A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Chemical ID: MESH:C065382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl3multiple interactionsISOCXCL1 (Homo sapiens)6480464CTDFluticasone inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]; TNF protein inhibits the reaction [Fluticasone inhibits the reaction [Particulate Matter results in increased secretion of CXCL1 protein]]PMID:31822346
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