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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:5132
Term: flutamide
Definition: A (trifluoromethyl)benzene that has formula C11H11F3N2O3.
Chemical ID: MESH:D005485
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases expressionEXP 6480464CTDFlutamide results in increased expression of ESR1 mRNA; Flutamide results in increased expression of ESR1 proteinPMID:11748029 PMID:16003321
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDFlutamide results in increased expression of ESR1 mRNAPMID:21128595
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDFlutamide binds to and results in increased activity of ESR1 proteinPMID:33049310
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