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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736887
Species: Mus musculus
RGD Object: Gene
Symbol: Hpgd
Name: hydroxyprostaglandin dehydrogenase 15 (NAD)
Acc ID: CHEBI:5130
Term: flurbiprofen
Definition: A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID: MESH:D005480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hpgddecreases degradationISOHPGD (Homo sapiens)6480464CTDFlurbiprofen results in decreased degradation of HPGD proteinPMID:19501039
Hpgdincreases activityISOHPGD (Homo sapiens)6480464CTDFlurbiprofen results in increased activity of HPGD proteinPMID:19501039
Hpgdincreases expressionISOHPGD (Homo sapiens)6480464CTDFlurbiprofen results in increased expression of HPGD mRNAPMID:19501039
Hpgdmultiple interactionsISOHPGD (Homo sapiens)6480464CTD[[Flurbiprofen results in increased expression of TIMP1 protein] which results in decreased expression of MMP9 mRNA] which results in decreased degradation of HPGD proteinPMID:19501039
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