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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1317784
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2C9
Name: cytochrome P450 family 2 subfamily C member 9
Acc ID: CHEBI:5130
Term: flurbiprofen
Definition: A monocarboxylic acid that is a 2-fluoro-[1,1'-biphenyl-4-yl] moiety linked to C-2 of propionic acid. A non-steroidal anti-inflammatory, analgesic and antipyretic, it is used as a pre-operative anti-miotic as well as orally for arthritis or dental pain.
Chemical ID: MESH:D005480
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2C9affects bindingEXP 6480464CTDFlurbiprofen binds to CYP2C9 proteinPMID:21053930
CYP2C9affects hydrolysisEXP 6480464CTDCYP2C9 gene polymorphism affects the hydrolysis of FlurbiprofenPMID:9698079
CYP2C9affects hydroxylationEXP 6480464CTDCYP2C9 protein affects the hydroxylation of FlurbiprofenPMID:15955872
CYP2C9affects metabolic processingEXP 6480464CTDCYP2C9 gene polymorphism affects the metabolism of FlurbiprofenPMID:11901091 PMID:18378563 PMID:25775139
CYP2C9increases hydrolysisEXP 6480464CTDCYP2C9 protein results in increased hydrolysis of FlurbiprofenPMID:9698079
CYP2C9increases hydroxylationEXP 6480464CTDCYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen; CYP2C9 protein results in increased hydroxylation of FlurbiprofenPMID:15130760 PMID:21053930
CYP2C9increases metabolic processingEXP 6480464CTDCYP2C9 protein results in increased metabolism of FlurbiprofenPMID:11901091 PMID:18378563 PMID:19082874
CYP2C9multiple interactionsEXP 6480464CTD3',4'-dimethoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 3-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 4'-methoxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 5-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 6,7-dihydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; 7-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; acacetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; alpha-naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Apigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Benzbromarone inhibits the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]; Benzbromarone promotes the reaction [CYP2C9 protein polymorphism affects the hydroxylation of Flurbiprofen]; beta-Naphthoflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; chrysin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Dapsone promotes the reaction [CYP2C9 protein polymorphism results in increased hydroxylation of Flurbiprofen]; Dapsone promotes the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; flavanone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; flavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Fluconazole affects the reaction [CYP2C9 gene polymorphism affects the metabolism of Flurbiprofen]; galangin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Genistein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; kaempferol inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; naringenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; naringin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]; Quercetin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen]PMID:15130760 PMID:15955872 PMID:18378563 PMID:21053930
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