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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731356
Species: Homo sapiens
RGD Object: Gene
Symbol: CAMK4
Name: calcium/calmodulin dependent protein kinase IV
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CAMK4decreases expressionISOCamk4 (Rattus norvegicus)6480464CTDFluoxetine results in decreased expression of CAMK4 mRNAPMID:17033635
CAMK4multiple interactionsISOCamk4 (Rattus norvegicus)6480464CTDFluoxetine results in increased phosphorylation of and results in increased activity of CAMK4 proteinPMID:15138445
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