GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | EGFR | increases phosphorylation | ISO | Egfr (Mus musculus) | 6480464 | CTD | Fluoxetine results in increased phosphorylation of EGFR protein | PMID:18758753 | EGFR | multiple interactions | ISO | Egfr (Mus musculus) | 6480464 | CTD | [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; [[Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; [Fluoxetine binds to and results in increased activity of HTR2C protein] which results in increased phosphorylation of and results in increased activity of EGFR protein; N-(2(R)-2-(hydroxamidocarbonylmethyl)-4-methylpentanoyl)-L-tryptophan methylamide inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein]; RTKI cpd inhibits the reaction [Fluoxetine results in increased phosphorylation of EGFR protein] | PMID:18758753 PMID:19662385 | | ||||||||||||||||||||||
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