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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69115
Species: Homo sapiens
RGD Object: Gene
Symbol: CDKN1B
Name: cyclin dependent kinase inhibitor 1B
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDKN1Baffects expressionEXP 6480464CTDFluoxetine affects the expression of CDKN1B mRNAPMID:18371935
CDKN1Bmultiple interactionsEXP 6480464CTD[Fluoxetine results in decreased activity of CKS1B protein] which results in decreased degradation of CDKN1B proteinPMID:18371935
CDKN1Bincreases expressionISOCdkn1b (Mus musculus)6480464CTDFluoxetine results in increased expression of CDKN1B mRNAPMID:21497159
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