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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348437
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP9decreases activityISOMmp9 (Rattus norvegicus)6480464CTDFluoxetine results in decreased activity of MMP9 proteinPMID:21966942
MMP9multiple interactionsISOMmp9 (Rattus norvegicus)6480464CTD[9,10-Dimethyl-1,2-benzanthracene co-treated with Raloxifene Hydrochloride co-treated with Fluoxetine] affects the expression of MMP9 proteinPMID:31332895
MMP9multiple interactionsISOMmp9 (Mus musculus)6480464CTDFluoxetine inhibits the reaction [TNFSF11 protein results in increased expression of MMP9 mRNA]PMID:15312242
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