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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10631
Species: Mus musculus
RGD Object: Gene
Symbol: Gdnf
Name: glial cell line derived neurotrophic factor
Acc ID: CHEBI:5118
Term: fluoxetine
Definition: A racemate comprising equimolar amounts of (R)- and (S)-fluoxetine. A selective serotonin reuptake inhibitor (SSRI), it is used (generally as the hydrochloride salt) for the treatment of depression (and the depressive phase of bipolar disorder), bullimia nervosa, and obsessive-compulsive disorder.
Chemical ID: MESH:D005473
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gdnfincreases expressionISOGdnf (Rattus norvegicus)6480464CTDFluoxetine results in increased expression of GDNF mRNAPMID:15456934
Gdnfmultiple interactionsISOGdnf (Rattus norvegicus)6480464CTDU 0126 inhibits the reaction [Fluoxetine results in increased expression of GDNF mRNA]PMID:15456934
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