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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61971
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kcnj5
Name: potassium inwardly-rectifying channel, subfamily J, member 5
Acc ID: CHEBI:51137
Term: mianserin
Definition: A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Chemical ID: MESH:D008803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kcnj5multiple interactionsISORGD:622646480464CTDMianserin affects the activity of [KCNJ3 mRNA co-treated with KCNJ5 mRNA]

PMID:22164246
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.