Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Htr2c
Name: 5-hydroxytryptamine receptor 2C
Acc ID: CHEBI:51137
Term: mianserin
Definition: A dibenzoazepine (specifically 1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine) methyl-substituted on N-2. Closely related to (and now mostly superseded by) the tetracyclic antidepressant mirtazapinean, it is an atypical antidepressant used in the treatment of depression throughout Europe and elsewhere.
Chemical ID: MESH:D008803
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Htr2cincreases expressionISORGD:7368426480464CTDMianserin results in increased expression of HTR2C protein

PMID:18083778
Htr2cmultiple interactionsISORGD:107486480464CTD[Mianserin binds to and results in decreased activity of HTR2C protein] which results in decreased susceptibility to Methamphetamine Mianserin binds to and results in decreased activity of HTR2C protein

PMID:10978843 PMID:15213358
Htr2cmultiple interactionsISORGD:7368426480464CTD6-chloro-5-methyl-1-2-2-methylpyrid-3-yloxypyrid-5-ylcarbamoylindoline inhibits the reaction [Mianserin results in increased expression of HTR2C protein] Mianserin binds to and affects the activity of HTR2C protein

PMID:18083778
Go Back to source page   Continue to Ontology report