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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620640
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d4
Name: cytochrome P450, family 2, subfamily d, polypeptide 4
Acc ID: CHEBI:51062
Term: (RS)-amphetamine
Definition: null
Definition Source(s): ChemIDplus:300-62-9, DrugBank:DB00182
Chemical ID: MESH:D000661
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
affects chemical synthesisISORGD:7362176480464CTDCYP2D6 protein affects the chemical synthesis of Amphetamine

PMID:15294457
decreases methylationISORGD:7362176480464CTDCYP2D6 protein results in decreased methylation of Amphetamine analog

PMID:29277574
increases hydroxylationISORGD:7362176480464CTDCYP2D6 protein results in increased hydroxylation of Amphetamine analog

PMID:29277574
increases oxidationISORGD:7362176480464CTDCYP2D6 protein results in increased oxidation of Amphetamine analog

PMID:29277574
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.