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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619791
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bub1b
Name: BUB1 mitotic checkpoint serine/threonine kinase B
Acc ID: CHEBI:51052
Term: lucanthone
Definition: A thioxanthen-9-one compound having a methyl substituent at the 1-position and a 2-[(diethylamino)ethyl]amino substituent at the 4-position. Formerly used for the treatment of schistosomiasis. It is a prodrug, being metabolised to hycanthone.
Chemical ID: MESH:D008154
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13163166480464CTDLucanthone results in decreased expression of BUB1B mRNA

PMID:21148553
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.