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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2651
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gabrb3
Name: gamma-aminobutyric acid type A receptor subunit beta 3
Acc ID: CHEBI:5103
Term: flumazenil
Definition: An organic heterotricyclic compound that is 5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine which is substituted at positions 3, 5, 6, and 8 by ethoxycarbonyl, methyl, oxo, and fluoro groups, respectively. It is used as an antidote to benzodiazepine overdose.
Chemical ID: MESH:D005442
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabrb3affects bindingISOGABRB3 (Homo sapiens)6480464CTDFlumazenil binds to [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]PMID:8632757
Gabrb3multiple interactionsISOGABRB3 (Homo sapiens)6480464CTDFlumazenil binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Flumazenil promotes the reaction [gamma-Aminobutyric Acid binds to and results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]PMID:8632757
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