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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732833
Species: Homo sapiens
RGD Object: Gene
Symbol: EIF4E
Name: eukaryotic translation initiation factor 4E
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EIF4Edecreases phosphorylationEXP 6480464CTDsorafenib results in decreased phosphorylation of EIF4E proteinPMID:16109713 PMID:21750559
EIF4Emultiple interactionsEXP 6480464CTD[sorafenib results in decreased phosphorylation of EIF4E protein] which results in decreased expression of MCL1; sorafenib inhibits the reaction [MKNK1 protein results in increased phosphorylation of EIF4E protein]PMID:16109713 PMID:21750559
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