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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731381
Species: Mus musculus
RGD Object: Gene
Symbol: Aifm1
Name: apoptosis-inducing factor, mitochondrion-associated 1
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Aifm1affects localizationISOAIFM1 (Homo sapiens)6480464CTDSorafenib affects the localization of AIFM1 proteinPMID:16109713 PMID:16959960 PMID:17991738 PMID:20054642
Aifm1multiple interactionsISOAIFM1 (Homo sapiens)6480464CTD[sorafenib co-treated with 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluorobenzamide] affects the localization of AIFM1 protein; [sorafenib co-treated with 6-bromoindirubin-3'-oxime] affects the localization of AIFM1 protein; [sorafenib co-treated with TNFSF10 protein] affects the localization of AIFM1 protein; GSK3B inhibits the reaction [sorafenib affects the localization of AIFM1 protein]PMID:17909059 PMID:17991738 PMID:20117835
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