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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionEXP 6480464CTDsorafenib analog results in decreased expression of CCND1 protein; sorafenib results in decreased expression of CCND1 mRNA; sorafenib results in decreased expression of CCND1 proteinPMID:16959960 PMID:17178882 PMID:17909054 PMID:19001435 PMID:19633425 PMID:19878585 PMID:21531053 PMID:25416439
CCND1multiple interactionsEXP 6480464CTD[sorafenib co-treated with letrozole] results in decreased expression of CCND1 protein; [sorafenib co-treated with rottlerin] results in decreased expression of CCND1 protein; arsenic trioxide promotes the reaction [sorafenib results in decreased expression of CCND1 protein]; sorafenib inhibits the reaction [Acids results in increased expression of CCND1 mRNA]; sorafenib inhibits the reaction [Acids results in increased expression of CCND1 protein]; sorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCND1 mRNA]; sorafenib inhibits the reaction [Taurocholic Acid results in increased expression of CCND1 protein]; sorafenib promotes the reaction [arsenic trioxide results in decreased expression of CCND1 protein]PMID:16959960 PMID:18512153 PMID:18840136 PMID:20054642 PMID:25416439
CCND1multiple interactionsISOCcnd1 (Rattus norvegicus)6480464CTDsorafenib inhibits the reaction [[Theophylline results in increased abundance of Cyclic AMP] which results in increased expression of CCND1 protein]; sorafenib inhibits the reaction [TSC2 protein mutant form results in increased expression of CCND1 protein]PMID:21693435 PMID:21813464
CCND1multiple interactionsISOCcnd1 (Mus musculus)6480464CTDSorafenib inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]PMID:29859236
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