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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621863
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atf4
Name: activating transcription factor 4
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atf4increases expressionISOATF4 (Homo sapiens)6480464CTD[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT3 mRNA; [sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT3 protein; [sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein; sorafenib results in increased expression of ATF4 mRNA; sorafenib results in increased expression of ATF4 proteinPMID:21601561
Atf4multiple interactionsISOATF4 (Homo sapiens)6480464CTD[[[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein] which results in decreased expression of BIRC5 protein; [[sorafenib results in increased expression of ATF4 protein] which results in increased expression of DDIT4 protein] which results in decreased activity of MTOR protein; sorafenib promotes the reaction [ATF4 protein results in increased expression of DDIT4 protein]PMID:21601561
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