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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2324
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdkn2b
Name: cyclin-dependent kinase inhibitor 2B
Acc ID: CHEBI:50924
Term: sorafenib
Definition: A member of the class of phenylureas that is urea in which one of the nitrogens is substituted by a 4-chloro-3-trifluorophenyl group while the other is substituted by a phenyl group which, in turn, is substituted at the para position by a [2-(methylcarbamoyl)pyridin-4-yl]oxy group.
Chemical ID: MESH:C471405
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdkn2bincreases expressionISOCdkn2b (Mus musculus)6480464CTDsorafenib results in increased expression of CDKN2B proteinPMID:19139124
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