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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10473
Species: Mus musculus
RGD Object: Gene
Symbol: Nqo1
Name: NAD(P)H dehydrogenase, quinone 1
Acc ID: CHEBI:50866
Term: 3H-1,2-dithiole-3-thione
Definition: A 1,2-dithiole that has formula C3H2S3.
Chemical ID: MESH:C049325
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nqo1increases activityEXP 6480464CTD1,2-dithiol-3-thione results in increased activity of NQO1 proteinPMID:18367636
Nqo1increases expressionEXP 6480464CTD1,2-dithiol-3-thione results in increased expression of NQO1 mRNA; 1,2-dithiol-3-thione results in increased expression of NQO1 proteinPMID:18367636 PMID:19785463 PMID:22959925
Nqo1multiple interactionsEXP 6480464CTD[1,2-dithiol-3-thione results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased activity of NQO1 protein]; NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased expression of NQO1 mRNA]; NFE2L2 gene mutant form inhibits the reaction [1,2-dithiol-3-thione results in increased expression of NQO1 protein]PMID:18367636 PMID:22495766
Nqo1increases activityISONQO1 (Homo sapiens)6480464CTD1,2-dithiol-3-thione results in increased activity of NQO1 proteinPMID:19408115
Nqo1increases expressionISONqo1 (Rattus norvegicus)6480464CTD1,2-dithiol-3-thione results in increased expression of NQO1 mRNAPMID:19162173 PMID:19695238
Nqo1increases expressionISONQO1 (Homo sapiens)6480464CTD1,2-dithiol-3-thione results in increased expression of NQO1 mRNAPMID:19408115 PMID:21464371
Nqo1multiple interactionsISONQO1 (Homo sapiens)6480464CTD1,2-dithiol-3-thione results in increased expression of and results in increased activity of NQO1 proteinPMID:25179160
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