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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69474
Species: Mus musculus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:50859
Term: bexarotene
Definition: A retinoid that has formula C24H28O2.
Chemical ID: MESH:C095105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Srebf1increases expressionISOSrebf1 (Rattus norvegicus)6480464CTDbexarotene results in increased expression of SREBF1 mRNAPMID:23292798
Srebf1increases expressionISOSREBF1 (Homo sapiens)6480464CTDBexarotene results in increased expression of SREBF1 mRNAPMID:32123961
Srebf1multiple interactionsISOSREBF1 (Homo sapiens)6480464CTD[Bexarotene co-treated with GW 3965] results in increased expression of SREBF1 mRNA; [Bexarotene co-treated with paxilline] results in increased expression of SREBF1 mRNA; [Bexarotene co-treated with T0901317] results in increased expression of SREBF1 mRNA; Bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of SREBF1 mRNA]PMID:25932594 PMID:32123961
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