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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68556
Species: Homo sapiens
RGD Object: Gene
Symbol: CCND1
Name: cyclin D1
Acc ID: CHEBI:50859
Term: bexarotene
Definition: A retinoid that has formula C24H28O2.
Chemical ID: MESH:C095105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCND1decreases expressionISOCcnd1 (Mus musculus)6480464CTDbexarotene results in decreased expression of CCND1 mRNAPMID:17178900
CCND1increases expressionISOCcnd1 (Rattus norvegicus)6480464CTDbexarotene results in increased expression of CCND1 mRNAPMID:16648578
CCND1multiple interactionsISOCcnd1 (Rattus norvegicus)6480464CTD[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of CCND1 protein]; Bexarotene affects the reaction [Azoxymethane affects the expression of CCND1 mRNA]; Bexarotene affects the reaction [Azoxymethane affects the expression of CCND1 protein]PMID:24080207
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