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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61909
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nr1h3
Name: nuclear receptor subfamily 1, group H, member 3
Acc ID: CHEBI:50859
Term: bexarotene
Definition: A retinoid that has formula C24H28O2.
Chemical ID: MESH:C095105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nr1h3decreases expressionISONR1H3 (Homo sapiens)6480464CTDBexarotene results in decreased expression of NR1H3 mRNAPMID:32123961
Nr1h3multiple interactionsISONR1H3 (Homo sapiens)6480464CTD[Bexarotene co-treated with GW 3965] results in increased expression of NR1H3 mRNA; [Bexarotene co-treated with paxilline] results in increased expression of NR1H3 mRNA; [Bexarotene co-treated with T0901317] results in increased expression of NR1H3 mRNA; Bexarotene promotes the reaction [[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone co-treated with INS protein] results in increased expression of NR1H3 mRNA]PMID:25932594 PMID:32123961
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