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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10552
Species: Mus musculus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2 (beta)
Acc ID: CHEBI:50859
Term: bexarotene
Definition: A retinoid that has formula C24H28O2.
Chemical ID: MESH:C095105
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2multiple interactionsISOEsr2 (Rattus norvegicus)6480464CTD[Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; [Raloxifene Hydrochloride co-treated with Bexarotene] affects the reaction [Azoxymethane affects the expression of ESR2 protein]; Bexarotene affects the reaction [Azoxymethane affects the expression of ESR2 mRNA]; Bexarotene affects the reaction [Azoxymethane affects the expression of ESR2 protein]PMID:24080207
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDbexarotene binds to and results in decreased activity of ESR2 proteinPMID:25752796
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