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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619830
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd40
Name: CD40 molecule
Acc ID: CHEBI:50847
Term: immunological adjuvant
Definition: A substance that augments, stimulates, activates, potentiates, or modulates the immune response at either the cellular or humoral level. A classical agent (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contains bacterial antigens. It could also be endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Its mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy is related to its antigen-specific immunoadjuvanticity.
Chemical ID: MESH:D000276
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd40increases expressionISOCD40 (Homo sapiens)6480464CTDAdjuvants, Immunologic results in increased expression of CD40 proteinPMID:11160013
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