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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730822
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp2
Name: matrix metallopeptidase 2
Acc ID: CHEBI:50845
Term: doxycycline
Definition: Tetracycline in which the 5beta-hydrogen is replaced by a hydroxy group, while the 6alpha-hydroxy group is replaced by hydrogen. A semi-synthetic tetracycline antibiotic, it is used to inhibit bacterial protein synthesis and treat non-gonococcal urethritis and cervicitis, exacerbations of bronchitis in patients with chronic obstructive pulmonary disease (COPD), and adult periodontitis.
Chemical ID: MESH:D004318
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp2decreases expressionEXP 6480464CTDDoxycycline results in decreased expression of MMP2 proteinPMID:18178469
Mmp2multiple interactionsEXP 6480464CTDDoxycycline inhibits the reaction [Isoproterenol results in increased activity of MMP2]PMID:18089841
Mmp2decreases activityISOMmp2 (Rattus norvegicus)6480464CTDDoxycycline results in decreased activity of MMP2 proteinPMID:20837116
Mmp2decreases activityISOMMP2 (Homo sapiens)6480464CTDDoxycycline analog results in decreased activity of MMP2 proteinPMID:17267227
Mmp2multiple interactionsISOMmp2 (Rattus norvegicus)6480464CTDDoxycycline inhibits the reaction [AGT protein modified form results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Lead results in increased expression of and results in increased activity of MMP2 protein]PMID:18836702 PMID:20837116
Mmp2multiple interactionsISOMMP2 (Homo sapiens)6480464CTDDoxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP2 protein]; Doxycycline inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]PMID:17498959 PMID:19375915
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