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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:50749
Term: calcipotriol
Definition: A seco-cholestane that is 26,27-cyclo-9,10-secocholesta-5,7,10,22-tetraene carrying additional hydroxy substituents at positions 1, 3 and 24. It is used (as its hydrate) in combination with betamethasone dipropionate, a corticosteroid, for the topical treatment of plaque psoriasis in adult patients.
Chemical ID: MESH:C055085
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1decreases expressionISORGD:692106480464CTDcalcipotriene results in decreased expression of CYP7A1 protein

PMID:30419252
Cyp7a1multiple interactionsISORGD:692106480464CTDcalcipotriene inhibits the reaction [VDR protein affects the expression of CYP7A1 protein]

PMID:30419252
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.