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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69097
Species: Homo sapiens
RGD Object: Gene
Symbol: LHB
Name: luteinizing hormone subunit beta
Acc ID: CHEBI:50743
Term: cyproterone acetate
Definition: A steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas.
Chemical ID: MESH:D017373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LHBdecreases expressionEXP 6480464CTDCyproterone Acetate results in decreased expression of LHB proteinPMID:11994349
LHBmultiple interactionsEXP 6480464CTD[Ethinyl Estradiol co-treated with Cyproterone Acetate] results in decreased expression of LHB proteinPMID:16002536
LHBincreases expressionISOLhb (Rattus norvegicus)6480464CTDCyproterone Acetate results in increased expression of LHB proteinPMID:20463352
LHBmultiple interactionsISOLhb (Rattus norvegicus)6480464CTDCyproterone Acetate inhibits the reaction [testosterone enanthate results in decreased expression of LHB protein]PMID:20463352 PMID:23085480
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