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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:50743
Term: cyproterone acetate
Definition: A steroid ester resulting from the formal condensation of the carboxy group of acetic acid with the 17-hydroxy group of cyproterone. It is an antiandrogenic drug which has recently been recognized to promote the occurrence and growth of intracranial meningiomas.
Chemical ID: MESH:D017373
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2decreases expressionISONos2 (Rattus norvegicus)6480464CTDCyproterone Acetate results in decreased expression of NOS2 mRNAPMID:20463352
Nos2multiple interactionsISONos2 (Rattus norvegicus)6480464CTDCyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 mRNA]; Cyproterone Acetate inhibits the reaction [testosterone enanthate results in increased expression of NOS2 protein]PMID:20463352 PMID:23085480
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