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RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMinocycline results in decreased expression of CASP12 mRNA, Minocycline results in decreased expression of CASP12 protein

multiple interactionsEXP 6480464CTDMinocycline inhibits the reaction [APP protein alternative form results in increased activity of CASP12 protein], Minocycline results in decreased degradation of [Paraquat results in increased expression of CASP12 protein]

PMID:17406652, PMID:22245251
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.