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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1322043
Species: Homo sapiens
RGD Object: Gene
Symbol: DIABLO
Name: diablo IAP-binding mitochondrial protein
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DIABLOdecreases secretionISODiablo (Mus musculus)6480464CTDMinocycline results in decreased secretion of DIABLO proteinPMID:12930891
DIABLOmultiple interactionsISODiablo (Rattus norvegicus)6480464CTDMinocycline inhibits the reaction [HTT protein mutant form results in increased secretion of DIABLO protein]; Minocycline results in decreased secretion of and results in decreased expression of DIABLO proteinPMID:12930891 PMID:14998631
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