Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10230
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2
Name: B cell leukemia/lymphoma 2
Acc ID: CHEBI:50694
Term: minocycline
Definition: A tetracycline analogue having a dimethylamino group at position 7 and lacking the methyl and hydroxy groups at position 5.
Chemical ID: MESH:D008911
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2increases expressionISOBcl2 (Rattus norvegicus)6480464CTDMinocycline results in increased expression of BCL2 mRNA; Minocycline results in increased expression of BCL2 proteinPMID:15004018 PMID:19807907 PMID:20711699
Bcl2multiple interactionsISOBcl2 (Rattus norvegicus)6480464CTD[Minocycline results in increased expression of BCL2 protein] which binds to BAK1 protein; [Minocycline results in increased expression of BCL2 protein] which binds to BAX protein; [Minocycline results in increased expression of BCL2 protein] which binds to BID protein; Sodium Azide inhibits the reaction [Minocycline results in increased expression of BCL2 protein]PMID:15004018
Bcl2multiple interactionsISOBCL2 (Homo sapiens)6480464CTD[Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2 protein] results in increased expression of BCL2 mRNA; [Minocycline co-treated with Hydrogen Peroxide co-treated with TGFB2] results in increased expression of BCL2 proteinPMID:20606027
Go Back to source page   Continue to Ontology report