GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PGR | affects activity | EXP | | 6480464 | CTD | Mifepristone affects the activity of PGR protein | PMID:1544902 | PGR | decreases activity | EXP | | 6480464 | CTD | Mifepristone results in decreased activity of PGR protein | PMID:15870863 | PGR | decreases expression | EXP | | 6480464 | CTD | Mifepristone results in decreased expression of PGR protein | PMID:22266097 | PGR | multiple interactions | EXP | | 6480464 | CTD | Mifepristone analog binds to and results in decreased activity of PGR protein; Mifepristone binds to and results in decreased activity of PGR protein; Mifepristone inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Mifepristone inhibits the reaction [[Progestins results in increased activity of PGR protein] which results in increased expression of VEGFA]; Mifepristone inhibits the reaction [methoxyacetic acid promotes the reaction [Promegestone results in increased activity of PGR protein]]; Mifepristone inhibits the reaction [Progesterone results in increased expression of PGR protein]; Mifepristone promotes the reaction [Progesterone affects the expression of PGR mRNA] | PMID:15103026 PMID:15811074 PMID:15845615 PMID:15925510 PMID:16601080 PMID:16806946 PMID:18262749 PMID:22414680 PMID:25752796 PMID:26022396 | PGR | multiple interactions | ISO | Pgr (Mus musculus) | 6480464 | CTD | Mifepristone binds to and results in decreased activity of PGR protein; Mifepristone inhibits the reaction [bisphenol A results in increased expression of PGR protein]; Mifepristone inhibits the reaction [octylphenol results in increased expression of PGR protein]; Mifepristone inhibits the reaction [Progesterone results in increased expression of PGR mRNA]; Mifepristone inhibits the reaction [Progesterone results in increased expression of PGR protein] | PMID:15509668 PMID:27264040 PMID:31566189 | PGR | multiple interactions | ISO | Pgr (Rattus norvegicus) | 6480464 | CTD | [Mifepristone binds to and results in decreased activity of PGR protein] which results in decreased susceptibility to Progesterone; [Mifepristone binds to and results in decreased activity of PGR protein] which results in increased expression of CCL2 mRNA; [Mifepristone binds to and results in decreased activity of PGR protein] which results in increased expression of CCL2 protein; Mifepristone binds to and results in decreased activity of PGR protein; Mifepristone inhibits the reaction [Progesterone results in increased expression of PGR mRNA] | PMID:10888668 PMID:18606702 PMID:19215433 PMID:19570671 PMID:20726854 | | ||||||||||||||||||||||
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