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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10510
Species: Mus musculus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:50692
Term: mifepristone
Definition: A 3-oxo steroid that has formula 429.59374.
Chemical ID: MESH:D015735
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:25426480464CTDMifepristone results in decreased expression of EGF mRNA

PMID:18591650
multiple interactionsISORGD:7368326480464CTDMifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to ARAF protein]]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to GRB2 protein]]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein promotes the reaction [EGFR protein binds to HRAS protein]]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAP2K1 protein]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]], Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [EGF protein results in increased phosphorylation of MAPK8 protein]], Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]], Mifepristone inhibits the reaction [Progesterone promotes the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]]

PMID:10807665, PMID:16175315
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.