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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605718
Species: Homo sapiens
RGD Object: Gene
Symbol: TFAM
Name: transcription factor A, mitochondrial
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFAMdecreases expressionISOTfam (Mus musculus)6480464CTDAtorvastatin results in decreased expression of TFAM proteinPMID:30511338
TFAMincreases expressionISOTfam (Rattus norvegicus)6480464CTDAtorvastatin results in increased expression of TFAM mRNAPMID:21775390
TFAMincreases expressionISOTfam (Mus musculus)6480464CTDAtorvastatin results in increased expression of TFAM mRNAPMID:30511338
TFAMmultiple interactionsISOTfam (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Atorvastatin results in increased expression of TFAM mRNA]PMID:21775390
TFAMmultiple interactionsISOTfam (Mus musculus)6480464CTD[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of TFAM mRNAPMID:30511338
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