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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347691
Species: Homo sapiens
RGD Object: Gene
Symbol: FASN
Name: fatty acid synthase
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASNincreases expressionEXP 6480464CTDAtorvastatin results in increased expression of FASN mRNAPMID:11728391
FASNincreases expressionISOFasn (Rattus norvegicus)6480464CTDAtorvastatin results in increased expression of FASN mRNAPMID:12056585
FASNmultiple interactionsISOFasn (Rattus norvegicus)6480464CTD[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Atorvastatin inhibits the reaction [[Fructose co-treated with Dietary Fats] results in increased expression of FASN protein]; Mevalonic Acid inhibits the reaction [Atorvastatin results in increased expression of FASN mRNA]PMID:12056585 PMID:32259528
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