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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3848
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tg
Name: thyroglobulin
Acc ID: CHEBI:50673
Term: methimazole
Definition: A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.
Chemical ID: MESH:D008713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tgdecreases expressionEXP 6480464CTDMethimazole results in decreased expression of TG mRNAPMID:30047161
Tgincreases expressionEXP 6480464CTDMethimazole results in increased expression of TG mRNAPMID:22342233
Tgmultiple interactionsEXP 6480464CTDMethimazole inhibits the reaction [TG protein affects the localization of IYD protein]PMID:30814441
Tgdecreases expressionISOTg (Mus musculus)6480464CTDMethimazole results in decreased expression of TG proteinPMID:17332529
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