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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10711
Species: Mus musculus
RGD Object: Gene
Symbol: Hmgb1
Name: high mobility group box 1
Acc ID: CHEBI:50673
Term: methimazole
Definition: A member of the class of imidazoles that it imidazole-2-thione in which a methyl group replaces the hydrogen which is attached to a nitrogen.
Chemical ID: MESH:D008713
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hmgb1increases expressionISOHmgb1 (Rattus norvegicus)6480464CTDMethimazole results in increased expression of HMGB1 mRNAPMID:30047161
Hmgb1multiple interactionsISOHmgb1 (Rattus norvegicus)6480464CTD[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]PMID:26177832
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