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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1566112
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Plekhd1
Name: pleckstrin homology and coiled-coil domain containing D1
Acc ID: CHEBI:50667
Term: mercaptopurine
Definition: A member of the class of purines that is 6,7-dihydro-1H-purine carrying a thione group at position 6. An adenine analogue, it is used in the treatment of acute lymphocytic leukemia (ALL), chronic myeloid leukemia (CML), Crohn's disease, and ulcerative colitis.
Chemical ID: MESH:D015122
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDMercaptopurine results in decreased expression of PLEKHD1 mRNA

PMID:23358152
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.