GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Alitretinoin results in decreased expression of IFNG mRNA; Alitretinoin results in decreased expression of IFNG protein | PMID:17118196 | Ifng | decreases secretion | ISO | Ifng (Mus musculus) | 6480464 | CTD | Alitretinoin results in decreased secretion of IFNG protein | PMID:11970994 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG promotes the reaction [STAT1 protein binds to CCL2 promoter]]; [22-hydroxycholesterol co-treated with Alitretinoin] inhibits the reaction [IFNG results in increased expression of STAT1 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased expression of NR1H3 mRNA]; Alitretinoin inhibits the reaction [IFNG results in increased phosphorylation of and results in increased localization of STAT1 protein] | PMID:21268089 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |