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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11484
Species: Mus musculus
RGD Object: Gene
Symbol: Vdr
Name: vitamin D (1,25-dihydroxyvitamin D3) receptor
Acc ID: CHEBI:50648
Term: 9-cis-retinoic acid
Definition: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Chemical ID: MESH:C103303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Vdraffects activityISOVDR (Homo sapiens)6480464CTDAlitretinoin affects the activity of VDR proteinPMID:16936639
Vdrincreases degradationISOVDR (Homo sapiens)6480464CTDAlitretinoin results in increased degradation of VDR proteinPMID:12898515
Vdrmultiple interactionsISOVDR (Homo sapiens)6480464CTD[Alitretinoin co-treated with Calcitriol] results in increased stability of [RXRA protein binds to VDR protein]; Alitretinoin promotes the reaction [VDR protein binds to BGLAP gene]PMID:12898515 PMID:16204233
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