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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10187
Species: Mus musculus
RGD Object: Gene
Symbol: Ar
Name: androgen receptor
Acc ID: CHEBI:5062
Term: finasteride
Definition: An aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.
Chemical ID: MESH:D018120
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Armultiple interactionsISOAr (Rattus norvegicus)6480464CTDFinasteride inhibits the reaction [Testosterone results in increased expression of AR mRNA]; Finasteride inhibits the reaction [Testosterone results in increased expression of AR protein]PMID:27687055 PMID:27866977
Armultiple interactionsISOAR (Homo sapiens)6480464CTDFinasteride inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein]; Finasteride inhibits the reaction [Metribolone results in increased activity of AR protein]PMID:18324785 PMID:33049310
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