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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10996
Species: Mus musculus
RGD Object: Gene
Symbol: Nos2
Name: nitric oxide synthase 2, inducible
Acc ID: CHEBI:50594
Term: carbon nanotube
Definition: A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.
Chemical ID: MESH:D037742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nos2affects expressionEXP 6480464CTDNanotubes, Carbon affects the expression of NOS2 mRNAPMID:25554681
Nos2increases expressionEXP 6480464CTDNanotubes, Carbon analog results in increased expression of NOS2 mRNA; Nanotubes, Carbon results in increased expression of NOS2 mRNA; Nanotubes, Carbon results in increased expression of NOS2 proteinPMID:21624382 PMID:22571318 PMID:25554681 PMID:32068018
Nos2multiple interactionsEXP 6480464CTD[Vancomycin co-treated with Neomycin co-treated with Cilastatin, Imipenem Drug Combination] inhibits the reaction [Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of NOS2 mRNA]]; IL1B protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of NOS2 mRNA]; Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of NOS2 mRNA]; TNF protein promotes the reaction [[Doxorubicin co-treated with Nanotubes, Carbon] results in increased expression of NOS2 mRNA]PMID:32068018
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