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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10802
Species: Mus musculus
RGD Object: Gene
Symbol: Il6
Name: interleukin 6
Acc ID: CHEBI:50594
Term: carbon nanotube
Definition: A molecule consisting of a graphene cylinder or two or more concentric graphene cylinders.
Chemical ID: MESH:D037742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il6affects expressionEXP 6480464CTDNanotubes, Carbon affects the expression of IL6 mRNAPMID:23845593
Il6decreases methylationEXP 6480464CTDNanotubes, Carbon results in decreased methylation of IL6 promoterPMID:31265265
Il6decreases secretionEXP 6480464CTDNanotubes, Carbon results in decreased secretion of IL6 proteinPMID:31265265
Il6increases expressionEXP 6480464CTDNanotubes, Carbon analog results in increased expression of IL6 mRNA; Nanotubes, Carbon results in increased expression of IL6; Nanotubes, Carbon results in increased expression of IL6 mRNA; Nanotubes, Carbon results in increased expression of IL6 proteinPMID:19428951 PMID:20381574 PMID:25216247 PMID:25510677 PMID:25554681 PMID:29112861
Il6increases secretionEXP 6480464CTDNanotubes, Carbon results in increased secretion of IL6 proteinPMID:19150385 PMID:19371758 PMID:22081859 PMID:24929217 PMID:25216247
Il6multiple interactionsEXP 6480464CTD[Aluminum Oxide co-treated with Nanotubes, Carbon] results in increased secretion of IL6 protein; [Dibutyl Phthalate co-treated with Nanotubes, Carbon] results in increased expression of IL6 proteinPMID:25216247 PMID:38285958
Il6decreases expressionISOIL6 (Homo sapiens)6480464CTDNanotubes, Carbon analog results in decreased expression of IL6 mRNAPMID:19041333
Il6decreases secretionISOIL6 (Homo sapiens)6480464CTDNanotubes, Carbon analog results in decreased secretion of IL6 proteinPMID:19041333
Il6increases expressionISOIL6 (Homo sapiens)6480464CTDNanotubes, Carbon analog results in increased expression of IL6 mRNA; Nanotubes, Carbon results in increased expression of IL6 mRNA; Nanotubes, Carbon results in increased expression of IL6 proteinPMID:20800606 PMID:22076105 PMID:24389112 PMID:25102311 PMID:25511174 PMID:27475286
Il6increases expressionISOIl6 (Rattus norvegicus)6480464CTDNanotubes, Carbon results in increased expression of IL6 proteinPMID:26589480
Il6increases secretionISOIL6 (Homo sapiens)6480464CTDNanotubes, Carbon analog results in increased secretion of IL6 protein; Nanotubes, Carbon results in increased secretion of IL6 proteinPMID:20800606 PMID:24389112 PMID:25216247 PMID:26370214 PMID:30802478
Il6multiple interactionsISOIL6 (Homo sapiens)6480464CTDAluminum Oxide inhibits the reaction [Nanotubes, Carbon results in increased secretion of IL6 protein]; Lipopolysaccharides promotes the reaction [Nanotubes, Carbon results in increased expression of IL6 protein]; Nanotubes, Carbon inhibits the reaction [calfactant results in increased expression of IL6 mRNA]; Nanotubes, Carbon promotes the reaction [[K-12 lipopolysaccharide binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein]; Nanotubes, Carbon promotes the reaction [[lipopolysaccharide, E coli O55-B5 binds to and results in increased activity of TLR4 protein] which results in increased secretion of IL6 protein]; Nanotubes, Carbon promotes the reaction [TLR2 protein results in increased secretion of IL6 protein]; TNF protein inhibits the reaction [Nanotubes, Carbon analog results in decreased secretion of IL6 protein]PMID:19041333 PMID:23266719 PMID:25216247 PMID:26589480 PMID:27475286
Il6multiple interactionsISOIl6 (Rattus norvegicus)6480464CTD[Nanotubes, Carbon co-treated with Dibutyl Phthalate] results in increased expression of IL6 mRNA; [Nanotubes, Carbon co-treated with Dibutyl Phthalate] results in increased expression of IL6 proteinPMID:37967788
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