GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Hmgb1 | affects expression | EXP | | 6480464 | CTD | Nanotubes, Carbon affects the expression of HMGB1 protein | PMID:21135415 | Hmgb1 | decreases expression | EXP | | 6480464 | CTD | Nanotubes, Carbon analog results in decreased expression of HMGB1 mRNA; Nanotubes, Carbon results in decreased expression of HMGB1 mRNA | PMID:25554681 | Hmgb1 | increases secretion | EXP | | 6480464 | CTD | Nanotubes, Carbon results in increased secretion of HMGB1 protein | PMID:31504961 | Hmgb1 | multiple interactions | EXP | | 6480464 | CTD | 2',3'-dialdehyde ATP inhibits the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]; [[Nanotubes, Carbon results in increased secretion of HMGB1 protein] which results in increased expression of and results in increased activity of AGER protein] which results in increased expression of RAC1 protein; [Nanotubes, Carbon results in increased secretion of HMGB1 protein] which results in increased expression of and results in increased activity of AGER protein; Adenosine Triphosphate promotes the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein]; Nanotubes, Carbon promotes the reaction [Doxorubicin results in increased expression of HMGB1 protein]; Nanotubes, Carbon results in increased localization of and results in increased secretion of HMGB1 protein; P2RX7 protein affects the reaction [Nanotubes, Carbon results in increased secretion of HMGB1 protein] | PMID:31504961 PMID:32068018 | | ||||||||||||||||||||||
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