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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Amultiple interactionsEXP 6480464CTD[Hemin results in decreased abundance of Iron] which results in increased expression of HIF1A mRNAPMID:12393473
HIF1Adecreases expressionISOHif1a (Mus musculus)6480464CTDHemin results in decreased expression of HIF1A mRNAPMID:29749404
HIF1Amultiple interactionsISOHif1a (Mus musculus)6480464CTD[HAMP mRNA results in decreased susceptibility to Hemin] which results in decreased expression of HIF1A mRNAPMID:29749404
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