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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:50385
Term: hemin
Definition: It is used as a prescription medication to relieve repeated attacks of acute intermittent porphyria related to the menstrual cycle in affected women.
Chemical ID: MESH:D006427
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxmultiple interactionsEXP 6480464CTDHemin inhibits the reaction [lead acetate results in increased expression of BAX protein]PMID:29797346
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDHemin results in increased expression of BAX proteinPMID:27815112
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDHemin promotes the reaction [Cisplatin results in increased expression of BAX protein]PMID:27815112
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